A shopper's guide for prescription drugs

How to navigate the maze of drug discounts to get the best price

March 29, 2026
By Sydney Lupkin

The recent introduction of TrumpRx in February adds to the increasing number of platforms designed to offer deals on prescription medications. However, many brand-name drugs available on TrumpRx may often be sourced at lower prices, particularly in the form of generics.

For instance, the cost of Protonix, a medication used for heartburn, is listed at $200 on TrumpRx, whereas its generic equivalent, pantoprazole, can be acquired for under $30 using a coupon from GoodRx. Additionally, when utilizing certain health insurance plans, it is possible to encounter a copay as low as $5 or even $0.

To navigate through options such as TrumpRx, GoodRx, Mark Cuban's Cost Plus Drugs, and other patient assistance resources effectively, consider the following strategies to secure the best pricing for your prescriptions.

1. Inquire about generics
   While your healthcare provider is prescribing your medication, ask if a generic version is available. If you neglect to do so, consulting your pharmacist can also be a wise step. Generic medications tend to be more affordable than their brand-name equivalents and are widely accessible at most pharmacies.

2. Discuss alternative medications
   In situations where a drug lacks a generic option, it is prudent to ask your physician about other pharmaceutical alternatives that are similarly categorized but may be offered at a lower cost. Your pharmacist can also provide essential information regarding alternative medications.

3. Communicate openly with your physician
   Should you discover that the cost of a necessary brand-name medication is prohibitively high, it is important to notify your prescribing doctor. They may be able to recommend alternative treatments that could be less expensive than your original prescription.

4. Compare prices
   Engage in price comparisons among different pharmacies and online platforms. The cost of the same medication can significantly fluctuate across various vendors, making it worthwhile to evaluate and contrast prices.

While the prescription landscape can be intricate, utilizing resources such as generics and having candid discussions with healthcare providers can lead to substantial savings in your healthcare expenditures.